Tau-Focused Immunotherapy for Alzheimers Disease and Related Tauopathies
نویسندگان
چکیده
منابع مشابه
Tau and tauopathies.
Tau protein is a neuronal microtubule-associated protein (MAP), which localizes primarily in the axon. It is one of the major and most widely distributed MAPs in the central nervous system. Its biochemistry and molecular pathology is being increasingly studied. Tau is a key component of neurofbrillary tangles in Alzheimer's disease (AD). Disorders with neuronal, oligodendroglial or astrocytic f...
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Tau is a microtubule-associated protein responsible mainly for stabilizing the neuronal microtubule network in the brain. Under normal conditions, tau is highly soluble and adopts an "unfolded" conformation. However, it undergoes conformational changes resulting in a less soluble form with weakened microtubule stabilizing properties. Altered tau forms characteristic pathogenic inclusions in Alz...
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ژورنال
عنوان ژورنال: Current Alzheimer Research
سال: 2009
ISSN: 1567-2050
DOI: 10.2174/156720509789207930